Exosomal microRNA remodels the tumor microenvironment

PeerJ

article

Xiaoli Jiang¹  Song Hu²  Qiang Liu³  Caiyun Qian¹  Zhuoqi Liu¹  Daya Luo¹ 

[1] Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Nanchang University;Queen Mary School, School of Medicine, Nanchang University;First Clinical Medical College, School of Medicine, Nanchang University;Jiangxi Province Key Laboratory of Tumor Pathogens and Molecular Pathology, Nanchang University

关键词: Endogenous;    Exogenous;    Exosome;    microRNA;    Tumor microenvironment;   

DOI  :  10.7717/peerj.4196

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Tumor occurrence, progression and metastasis depend on the crosstalk between tumor cells and stromal cells and on extrinsic factors outside the tumor microenvironment. Exosomal microRNA (miRNA) not only is involved in communications within the tumor microenvironment but also mediates communications between the extrinsic environment and tumor microenvironment. However, most reviews have been limited to the role of endogenous exosomal miRNA in remodeling the tumor microenvironment. Hence, we herein review the role of endogenous exosomal miRNA in mediating intercellular crosstalk within the tumor microenvironment, inducing the formation of the premetastatic niche. To place our vision outside the microenvironment, we also summarize for the first time the most recent studies regarding how exogenous miRNA derived from milk, plants and microbes influences the tumor microenvironment. Furthermore, to improve the value of exosomal miRNA in cancer research and clinical applications, we also provide some novel ideas for future research based on the comprehensive role of exosomal miRNA in remodeling the tumor microenvironment.

【 授权许可】

CC BY