Associations between brain activity and endogenous and exogenous cortisol - A systematic review

PSYCHONEUROENDOCRINOLOGY

卷:120

Review

Harrewijn, Anita¹  Vidal-Ribas, Pablo²  Clore-Gronenborn, Katharina^3,4  Jackson, Sarah M.¹  Pisano, Simone^5,6  Pine, Daniel S.¹  Stringaris, Argyris¹ 

[1] NIMH, Emot & Dev Branch, 9000 Rockville Pike, Bethesda, MD 20892 USA

[2] NICHHD, Social & Behav Sci Branch, 6710 Rockledge Dr, Bethesda, MD 20892 USA

[3] Case Western Reserve Univ, Lerner Coll Med, Cleveland Clin, 9501 Euclid Ave EC10, Cleveland, OH 44195 USA

[4] NIMH, Genet Epidemiol Res Branch, 9000 Rockville Pike, Bethesda, MD 20892 USA

[5] AORN Santobono Pausilipon, Dept Neurosci, Via Mario Fiore 6, Naples, Italy

[6] Univ Naples Federico II, Dept Translat Med Sci, Via Pansini 5, Naples, Italy

关键词: Cortisol;    Endogenous;    Exogenous;    fMRI;    Psychological stress;   

DOI  :  10.1016/j.psyneuen.2020.104775

来源: Elsevier

【 摘 要 】

To arrive at a coherent understanding of the relation between glucocorticoids and the human brain, we systematically reviewed the literature for studies examining the associations between endogenous or exogenous cortisol and human brain function. Higher levels of endogenous cortisol during psychological stress were related to increased activity in the middle temporal gyrus and perigenual anterior cingulate cortex (ACC), decreased activity in the ventromedial prefrontal cortex, and altered function (i.e., mixed findings, increased or decreased) in the amygdala, hippocampus and inferior frontal gyrus. Moreover, endogenous cortisol response to psychological stress was related to increased activity in the inferior temporal gyrus and altered function in the amygdala during emotional tasks that followed psychological stress. Exogenous cortisol administration was related to increased activity in the postcentral gyrus, superior frontal gyrus and ACC, and altered function in the amygdala and hippocampus during conditioning, emotional and reward-processing tasks after cortisol administration. These findings were in line with those from animal studies on amygdala activity during and after stress.

【 授权许可】

Free