One-pot multicomponent nitro-Mannich reaction using a heterogeneous catalyst under solvent-free conditions

PeerJ

article

Giovanna Bosica¹  Ramon Zammit¹ 

[1] Department of Chemistry, University of Malta

关键词: Heterogeneous catalyst;    Nitro-Mannich;    Solvent-free;    Multicomponent;    One-pot;   

DOI  :  10.7717/peerj.5065

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

An environmentally-friendly, one-pot multicomponent reaction of various aldehydes, amines and nitroalkanes for the synthesis of β-nitroamines is here described. Amberlyst A-21 supported CuI was found to be a highly efficient novel heterogeneous catalyst for the three-component nitro-Mannich reaction between aldehydes, amines and nitroalkanes. The developed protocol is performed in a solvent-free medium to produce a variety of β-nitroamines in good to excellent yields within short reaction times. The catalyst can be easily prepared and recovered. It has been tested up to eight times with only a minor activity loss.

【 授权许可】

CC BY