Rapid One-pot, Four Component Synthesis of Pyranopyrazoles Using Heteropolyacid Under Solvent-free Condition

Bulletin of the Korean chemical society

Hemant V. Chavan¹  Rahul U. Hoval¹  Babasaheb P. Bandgar¹  Santosh B. Babar¹ 

关键词: Pyranopyrazoles;    Multicomponent;    Heteropolyacid;    Solvent-free;    NOE;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

A series of pyranopyrazoles, was efficiently synthesized via one-pot, four component reaction of ethyl acetoacetate, hydrazine hydrate, aldehydes and malononitrile in the presence of catalytic amount silicotungstic acid under solvent free condition. NOE experiments confirmed that the product exist exclusively in the 2H form. The present protocol offers the advantages of clean reaction, short reaction time, high yield, easy purification and economic availability of the catalyst.

【 授权许可】

Unknown