An environmentally benign approach for the synthesis of 3,4,5-trisubstituted 2-aminofurans under solvent-free conditions via isocyanide-based multicomponent approach

TETRAHEDRON LETTERS

卷:57

Article

Shah, Tariq A.¹  Ahmad, Zubair¹  Rath, N. P.^2,3  Muneer, M.¹ 

[1] Aligarh Muslim Univ, Dept Chem, Aligarh 202002, Uttar Pradesh, India

[2] Univ Missouri, Dept Chem & Biochem, St Louis, MO 63121 USA

[3] Univ Missouri, Ctr Nanosci, St Louis, MO 63121 USA

关键词: Multicomponent;    Dibenzoylacetylene;    2-Aminofurans;    Isocyanide;    Solvent-free;   

DOI  :  10.1016/j.tetlet.2016.05.007

来源: Elsevier

【 摘 要 】

An efficient solvent-free procedure for the synthesis of 3,4,5-trisubstituted 2-aminofurans has been developed via a multicomponent strategy by the solid state condensation of finely grounded dibenzoylacetylene and aromatic aldehydes in the presence of isocyanides at room temperature. Clean reaction profile, easy work-up procedure, non-chromatographic purification technique, short reaction times, high yields, and solvent-free reaction conditions are the remarkable advantages of this procedure. Single crystal X-ray diffraction has been established for four structures. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

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