Association of circulating microRNA-122 with presence and severity of atherosclerotic lesions

PeerJ

article

Yu-Long Wang¹  Wen Yu² 

[1] Department of Cardiology, Haiyan People’s Hospital;Department of Geriatric, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College

关键词: microRNA-122;    Coronary heart disease;    Biomarker;    Atherosclerosis;   

DOI  :  10.7717/peerj.5218

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Objective MicroRNA (miR)-122 is highly expressed in the liver, where it has been implicated as a regulator of fatty-acid metabolism. A recent study reported that miR-122 plays a role in pathogenesis of atherosclerosis; however, whether it connects with severity of atherosclerotic lesion is still controversial. We therefore investigated the association between miR-122 expression and presence and severity of coronary atherosclerotic plaque. Methods During January–November 2017, we included 300 patients with coronary heart disease (CHD) and 100 subjects as the control group. MiR-122 content was detected by quantitative real-time polymerase chain reaction. MiR-122 level was identified in all subjects, and the Spearman correlation between miR-122 and severity of atherosclerosis was analyzed. Results Patients with CHD had higher miR-122 expression than in control group (2.61, 0.91–8.86 vs. 1.62, 0.71–3.45, p < 0.001). Gensini score was significantly associated with miR-122 expression (r = 0.7964, p < 0.001). The odds ratio of miR-122 solely was 0.12 (95% CI [0.05–0.43]) and factors such as cholesterol, triglyceride together with miR-122 level were closely associated with atherosclerosis (all p < 0.001). Conclusions The serum level of miR-122 may be used to differentiate between mild and severe coronary atherosclerotic lesion. Use of this marker might allow non-invasive diagnosis the degree of coronary atherosclerosis.

【 授权许可】

CC BY