NCR3 polymorphism, haematological parameters, and severe malaria in Senegalese patients

PeerJ

article

Alassane Thiam¹  Sabrina Baaklini²  Babacar Mbengue³  Samia Nisar²  Maryam Diarra⁴  Sandrine Marquet²  Mouhamadou Mansour Fall⁵  Michel Sanka²  Fatou Thiam¹  Rokhaya Ndiaye Diallo¹  Magali Torres²  Alioune Dieye¹  Pascal Rihet² 

[1] Unité d’Immunogénétique, Institut Pasteur de Dakar;Aix Marseille Univ;Service d’Immunologie, University Cheikh Anta Diop of Dakar;G4 Biostatistique, Institut Pasteur de Dakar;Service de Réanimation, Hôpital Principal de Dakar

关键词: Genetic association;    Mild malaria;    Severe malaria;    Plasmodium falciparum;    Host factors;   

DOI  :  10.7717/peerj.6048

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

BackgroundHost factors, including host genetic variation, have been shown to influence the outcome of Plasmodium falciparum infection. Genome-wide linkage studies have mapped mild malaria resistance genes on chromosome 6p21, whereas NCR3-412 polymorphism (rs2736191) lying within this region was found to be associated with mild malaria.MethodsBlood samples were taken from 188 Plasmodium falciparum malaria patients (76 mild malaria patients, 85 cerebral malaria patients, and 27 severe non-cerebral malaria patients). NCR3-412 (rs2736191) was analysed by sequencing, and haematological parameters were measured. Finally, their association with clinical phenotypes was assessed.ResultsWe evidenced an association of thrombocytopenia with both cerebral malaria and severe non-cerebral malaria, and of an association of high leukocyte count with cerebral malaria. Additionally, we found no association of NCR3-412 with either cerebral malaria, severe non-cerebral malaria, or severe malaria after grouping cerebral malaria and severe non-cerebral malaria patients.ConclusionsOur results suggest that NCR3 genetic variation has no effect, or only a small effect on the occurrence of severe malaria, although it has been strongly associated with mild malaria. We discuss the biological meaning of these results. Besides, we confirmed the association of thrombocytopenia and high leukocyte count with severe malaria phenotypes.

【 授权许可】

CC BY