PeerJ | |
NCR3 polymorphism, haematological parameters, and severe malaria in Senegalese patients | |
Sandrine Marquet1  Magali Torres1  Pascal Rihet1  Samia Nisar1  Sabrina Baaklini1  Michel Sanka1  Maryam Diarra2  Mouhamadou Mansour Fall3  Babacar Mbengue4  Alioune Dieye5  Alassane Thiam5  Fatou Thiam5  Rokhaya Ndiaye Diallo5  | |
[1] Aix Marseille Univ, INSERM, TAGC, Marseille, France;G4 Biostatistique, Institut Pasteur de Dakar, Dakar, Sénégal;Service de Réanimation, Hôpital Principal de Dakar, Dakar, Senegal;Service d’Immunologie, University Cheikh Anta Diop of Dakar, Dakar, Senegal;Unité d’Immunogénétique, Institut Pasteur de Dakar, Dakar, Senegal; | |
关键词: Genetic association; Mild malaria; Severe malaria; Plasmodium falciparum; Host factors; | |
DOI : 10.7717/peerj.6048 | |
来源: DOAJ |
【 摘 要 】
Background Host factors, including host genetic variation, have been shown to influence the outcome of Plasmodium falciparum infection. Genome-wide linkage studies have mapped mild malaria resistance genes on chromosome 6p21, whereas NCR3-412 polymorphism (rs2736191) lying within this region was found to be associated with mild malaria. Methods Blood samples were taken from 188 Plasmodium falciparum malaria patients (76 mild malaria patients, 85 cerebral malaria patients, and 27 severe non-cerebral malaria patients). NCR3-412 (rs2736191) was analysed by sequencing, and haematological parameters were measured. Finally, their association with clinical phenotypes was assessed. Results We evidenced an association of thrombocytopenia with both cerebral malaria and severe non-cerebral malaria, and of an association of high leukocyte count with cerebral malaria. Additionally, we found no association of NCR3-412 with either cerebral malaria, severe non-cerebral malaria, or severe malaria after grouping cerebral malaria and severe non-cerebral malaria patients. Conclusions Our results suggest that NCR3 genetic variation has no effect, or only a small effect on the occurrence of severe malaria, although it has been strongly associated with mild malaria. We discuss the biological meaning of these results. Besides, we confirmed the association of thrombocytopenia and high leukocyte count with severe malaria phenotypes.
【 授权许可】
Unknown