Short-term interval aerobic exercise training does not improve memory functioning in relapsing-remitting multiple sclerosis—a randomized controlled trial

PeerJ

article

Lisa Baquet¹  Helge Hasselmann²  Stefan Patra³  Jan-Patrick Stellmann¹  Eik Vettorazzi⁵  Andreas K. Engel⁶  Sina Cathérine Rosenkranz¹  Jana Poettgen¹  Stefan Michael Gold¹  Karl-Heinz Schulz³  Christoph Heesen¹ 

[1] Institute for Neuroimmunology and Multiple Sclerosis ,(INIMS), University Medical Center Hamburg-Eppendorf;Department for Psychiatry and Psychotherapy, Charité—Universitätsmedizin Berlin, Campus Benjamin Franklin;Universitäres Kompetenzzentrum für Sport- und Bewegungsmedizin ,(Athleticum) und Institut und Poliklinik für Medizinische Psychologie, University Medical Center Hamburg-Eppendorf;Department of Neurology, University Medical Center Hamburg-Eppendorf;Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf;Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf

关键词: Multiple sclerosis;    Cognition;    Memory function;    Aerobic exercise training;    Neuroimmunology;    Neurorehabilitation;   

DOI  :  10.7717/peerj.6037

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Background Only few aerobic exercise intervention trials specifically targeting cognitive functioning have been performed in multiple sclerosis. Objective and Methods This randomized controlled trial with 34 patients in the intervention group (IG) (mean: 38.2 years (±9.6)) and 34 patients in the control group (CG) (mean: 39.6 years (±9.7)) aimed to determine the effects of aerobic exercise on cognition in relapsing-remitting multiple sclerosis (RRMS). The primary outcome was verbal learning assessed by the verbal learning and memory test (VLMT). Patients were randomized to an IG or a waitlist CG. Patients in the IG exercised according to an individually tailored training schedule (with two to three sessions per week for 12 weeks). The primary analysis was carried out using the intention-to-treat (ITT) sample with ANCOVA adjusting for baseline scores. Results A total of 77 patients with RRMS were screened and 68 participants randomized (CG n = 34; IG n = 34). The sample comprised 68% females, had a mean age of 39 years, a mean disease duration of 6.3 years, and a mean expanded disability status scale of 1.8. No significant effects were detected in the ITT analysis for the primary endpoint VLMT or any other cognitive measures. Moreover, no significant treatment effects were observed for quality of life, fatigue, or depressive symptoms. Conclusion This study failed to demonstrate beneficial effects of aerobic exercise on cognition in RRMS. The trial was prospectively registered at clinicaltrials.gov (NCT02005237).

【 授权许可】

CC BY