Clinical characteristics and prognosis of basaloid squamous cell carcinoma of the lung: a population-based analysis

PeerJ

article

Guangda Yuan¹  Cheng Zhan²  Yiwei Huang²  Donglin Zhu¹  Hongya Xie¹  Tengteng Wei¹  Tao Lu²  Qun Wang²  Yong Yang¹  Yimeng Zhu¹ 

[1] Department of Thoracic Surgery, The Affiliated Suzhou Hospital of Nanjing Medical University;Department of Thoracic Surgery, Zhongshan Hospital, Fudan University

关键词: Basaloid squamous cell carcinoma (BSC);    Clinical characteristics;    Nomogram;    SEER database;   

DOI  :  10.7717/peerj.6724

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

BackgroundThis study analyzed the clinical features and prognosis of basaloid squamous cell carcinoma of the lung (BSC), and constructed a nomogram to predict the prognoses of patients.MethodsThe information of pure BSC patients was obtained in the Surveillance, Epidemiology, and End Results database between 2004 and 2015. Then, it was evaluated, and compared with the data of lung squamous cell carcinoma (SCC), lung large cell carcinoma (LCC) and lung adenocarcinoma (LAC) patients. Subsequently, we used univariate and multivariate analyses to investigate the independent factors related to the prognoses of patients with BSC and constructed a nomogram to verify the prognoses.ResultsA total of 425 patients diagnosed with BSC were enrolled. Compared with patients with SCC, LCC and LAC, the mean survival time of BSC patients was better than all of them. Compared with SCC, there were significant differences between the characteristics of grade (P < 0.001), total stage (P < 0.001), T stage (P < 0.001), N stage (P < 0.001), M stage (P < 0.001), surgery (P < 0.001), radiotherapy (P < 0.001), and chemotherapy (P < 0.001), while BSC also had significantly different clinical characteristics from LCC and LAC. Univariate and multivariate survival analyses showed that age (P < 0.001), T stage (P < 0.001), N stage (P = 0.009), M stage (P < 0.001), and surgery (P < 0.001) were independent prognostic factors of BSC. The survival of patients undergoing lobectomy was significantly better than sublobar resection, with an OR of 0.389 (0.263–0.578). We constructed a nomogram with a C-index of 0.750 (95% confidence interval) based on the results of multivariate analysis. The calibration curves based on nomogram scores indicated that the nomogram could accurately predict the prognosis of patients.ConclusionsBSC had unique clinical and prognostic features. T stage, N stage, M stage, age, and surgery were independently associated with overall survival (OS). Lobectomy was a relative ideal choice for patients with BSC. The nomogram effectively predicted the OS at 1-, 3-, and 5-years.

【 授权许可】

CC BY