Serum concentration of ubiquitin c-terminal hydrolase-L1 in detecting severity of traumatic brain injury

1st International Conference on Tropical Medicine and Infectious Diseases (ICTROMI) Faculty of Medicine Universitas Sumatera Utara

Siahaan, A.M.P.^1 ; Japardi, I.^1 ; Hakim, A.A.^1

Department of Neurosurgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia^1

关键词: Clinical characteristics;    Clinical utility;    Head injuries;    Mild head injury;    Neuronal damage;    Physical examinations;    Serum concentration;    Traumatic Brain Injuries;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/125/1/012207/pdf
DOI  :  10.1088/1755-1315/125/1/012207

来源: IOP

【 摘 要 】

One of the main problems with ahead injury is assessing the severity. While physical examination and imaging had limitations, neuronal damage markers, ubiquitin C-terminal hydrolase-L1 (UCH-L1), released in theblood may provide valuable information about diagnosis the traumatic brain injury (TBI).Analyzing the concentrations of serum ubiquitin C-terminal hydrolase-L1 (UCH-L1), there must have a neuronal injury biomarker, in theTBI patients serum and their association with clinical characteristics and outcome. There were 80 TBI subjects, and there are mild, moderate, and severe involved in this study of case- control. By using ELISA, we studied the profile of serum UCH-L1 levels for TBI patients. TheUCH-L1 serum level of moderate and severe head injury is higher than in mild head injury (p