Rutin ameliorates carbon tetrachloride (CCl 4 )-induced hepatorenal toxicity and hypogonadism in male rats

PeerJ

article

Hany Elsawy¹  Gehan M. Badr³  Azza Sedky³  Basem M. Abdallah³  Abdullah M. Alzahrani³  Ashraf M. Abdel-Moneim³ 

[1] Department of Chemistry, Faculty of Science, King Faisal University;Department of Chemistry, Faculty of Science, Tanta University;Department of Biological Sciences, Faculty of Science, King Faisal University;Department of Zoology, Faculty of Science, Ain Shams University;Department of Zoology, Faculty of Science, Alexandria University;Endocrine Research ,(KMEB), Department of Endocrinology, Odense University Hospital and University of Southern Denmark

关键词: Carbon tetrachloride;    Hepatorenal failure;    Rutin;    Hypogonadism;    Dyslipidemia;    Oxidative stress;   

DOI  :  10.7717/peerj.7011

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Rutin, a food derived-polyphenolic bioflavonoid, has been acknowledged for several health benefits. This study aims to explore the ameliorative effects of rutin against carbon tetrachloride (CCl4) toxicity in male rats. Adult male rats were given either CCl4 (30% in olive oil, 3 ml/kg b.w. intraperitoneally) alone or in combination with rutin (70 mg/kg intragastrically) twice a week for 4 weeks. Our data showed that rutin mitigated CCl4 hepatorenal damage, as indicated by diagnostic markers (i.e., transaminases, alkaline phosphatase, total bilirubin, total protein, albumin, urea, uric acid and creatinine), and histopathological findings. In addition, CCl4 induced profound elevation of free radical generation and oxidative stress, as evidenced by increasing lipid peroxidation and reducing catalase, superoxide dismutase and glutathione peroxidase activities in liver, kidney and testicular tissues; these effects were suppressed by coexposure with rutin. Moreover, the increase in the levels of serum triglycerides, cholesterol, low-density lipoprotein cholesterol, and very-low-density lipoprotein cholesterol induced by CCl4 was effectively counteracted by rutin. The decrease in the level of high-density lipoprotein cholesterol in the CCl4 group was also counteracted by rutin treatment. Interestingly, the decreased levels of hormonal mediators associated with sperm production, including serum testosterone, luteinizing hormone and follicle-stimulating hormone, and the impaired sperm quality induced by CCl4 were reversed by rutin. Data from the current study clearly demonstrated that rutin supplementation could at least partly overcome CCl4-induced hepatotoxicity, nephrotoxicity and reproductive toxicity by antioxidant and antidyslipidemic effects.

【 授权许可】

CC BY