Updated advances of linking psychosocial factors and sex hormones with systemic lupus erythematosus susceptibility and development

PeerJ

article

Qingjun Pan¹  Xiaoqun Chen¹  Shuzhen Liao¹  Xiaocui Chen¹  Chunfei Zhao¹  Yong-zhi Xu¹  Hua-feng Liu¹ 

[1] Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Institute of Nephrology, Division of Nephrology, Affiliated Hospital of Guangdong Medical University

关键词: Systemic lupus erythematosus;    Psychosocial factors;    Sex hormones;    Risk factors;    Therapy targets;   

DOI  :  10.7717/peerj.7179

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that primarily affects women, especially those of reproductive age. Genetics, environment, and gene-environment interactions play key roles in the development of SLE. Despite the numerous susceptibility genes of SLE identified to date, gene therapy is far from a clinical reality. Thus, more attention should be paid to the risk factors and underlying mechanisms of SLE. Currently, it is reported that psychosocial factors and sex hormones play vital roles in patients with SLE, which still need further investigated. The purpose of this review is to update the roles and mechanisms of psychosocial factors and sex hormones in the susceptibility and development of SLE. Based on review articles and reports in reputable peer-reviewed journals and government websites, this paper summarized psychosocial factors (e.g., alexithymia, depression, anxiety, negative emotions, and perceived stress) and sex hormones (e.g., estrogens, progesterone, androgens, and prolactin) involved in SLE. We further explore the mechanisms linking these factors with SLE susceptibility and development, which can guide the establishment of practical measures to benefit SLE patients and offer new ideas for therapeutic strategies.

【 授权许可】

CC BY