Nomogram to predict the prognosis of parotid gland mucoepidermoid carcinoma: a population-based study of 1306 cases

PeerJ

article

Jian Sun¹  Yang Sun¹  Fei Yang¹  Qianrong Zhou¹  Wenjuan Liu¹  Yong Cheng¹  Xingwen Wu¹  Tinglan Chen¹  Ruixue Li¹  Borui Huang¹  Wael Att³  Youcheng Yu¹  Wei Bi¹ 

[1] Department of Stomatology, Zhongshan Hospital, Fudan University;Department of Stomatology, Xuhui Central Hospital;Department of Prosthodontics, School of Dentistry, Albert Ludwigs University;Department of Prosthodontics, Dental Medicine, Tufts University School

关键词: Mucoepidermoid carcinoma;    Parotid gland;    Prognosis;    Nomogram;    SEER database;   

DOI  :  10.7717/peerj.7237

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

BackgroundMucoepidermoid carcinoma (MEC) is a common cancer in the oral salivary gland malignancy, which mainly occurs in the parotid gland. The aim of this study is to identify independent prognostic factors and establish a nomogram model for parotid gland mucoepidermoid carcinoma (P-MEC) patients using the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) database.MethodPatients with P-MEC were selected from between 2004 and 2015. The overall survival (OS) and cancer-specific survival (CSS) rates were estimated using the Kaplan-Meier method with the log-rank test. Univariate and multivariate Cox proportional hazards regression analyses were performed to identify the independent prognostic factors.ResultsA total of 1,306 patients with P-MEC were enrolled. Age, grade, T stage, N stage, M stage, chemotherapy, and surgery type were independent prognostic factors for OS and CSS. A nomogram for OS was formulated based on these independent prognostic factors and validated using an internal bootstrap resampling approach, which showed that the nomogram exhibited a sufficient level of discrimination according to the C-index (0.877, 95% CI [0.855–0.898]).ConclusionSeveral prognostic factors for P-MEC were identified. The nomogram developed in this study accurately predicted the 5- and 10-year OS rates of American patients with P-MEC based on individual characteristics. Risk stratification using the survival nomogram can optimize individual therapies and follow-up.

【 授权许可】

CC BY