Primary tracheobronchial mucoepidermoid carcinoma - a retrospective study of 32 patients

World Journal of Surgical Oncology

Yiping Zhang²  Huineng Zhu¹  Jiwen Wang³  Zhuo Liu³  Zhengbo Song² 

[1] Department of Pathology, Zhejiang Cancer Hospital, 38 GuangjiRoad, Gongshu District, Hangzhou 310022, P.R. of China;Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology, 38 GuangjiRoad, Gongshu District, Hangzhou, Zhejiang Province 310022, P.R. of China;Department of Oncological Surgery, Zhejiang Cancer Hospital, 38 GuangjiRoad, Gongshu District, Hangzhou 310022, P.R. of China

关键词: Prognosis;    Treatment;    Mucoepidermoid carcinoma;    Tracheobronchial;   

Others  :  825935
DOI  :  10.1186/1477-7819-11-62

 received in 2012-10-17, accepted in 2013-02-24,  发布年份 2013

【 摘 要 】

Background

This retrospective study was designed to investigate the clinical characteristics, diagnosis, treatment and prognosis of primary tracheobronchial mucoepidermoid carcinoma (MEC).

Methods

Clinical data were retrospectively analyzed from 32 patients with pathologically confirmed primary tracheobronchial MEC between January 1990 and December 2010 at Zhejiang Cancer Hospital. The Kaplan-Meier methods were used to estimate and compare survival rates.

Results

There were 19 males and 13 females ranging in age from 7 to 73 years, with a median age of 28 years. Twenty-six of the 32 patients were treated with surgery alone. The other six patients were treated with surgery plus postoperative radiotherapy or chemotherapy. Six patients died during the follow-up time. The overall five-year survival rates were 81.25%, whereas the five-year survival rate of seven patients with high-grade tumors was only 28.6%. Stage I and II patients experienced better survival than Stage III and IV patients (the five-year survival rate was 100% and 43.6% respectively, P<0.001).

Conclusions

Primary tracheobronchial MEC is a rare disease. Histologic grading and TNM (tumor-node-metastasis)staging are independent prognostic factors. Surgical resection is the primary treatment.

【 授权许可】

   
2013 Song et al; licensee BioMed Central Ltd.

【 图 表 】

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【 参考文献 】

• [1]Miller DL, Allen MS: Rare pulmonary neoplasms. Mayo ClinProc 1993, 68:492-498.
• [2]Kang DY, Yoon YS, Kim HK, Choi YS, Kim K, Shim YM, Kim J: Primary salivary gland-type lung cancer: surgical outcomes. Lung Cancer 2011, 72:250-254.
• [3]Molina JR, Aubry MC, Lewis JE, Wampfler JA, Williams BA, Midthun DE, Yang P, Cassivi SD: Primary salivary gland-type lung cancer: spectrum of clinical presentation, histopathologic and prognostic factors. Cancer 2007, 15:2253-2259.
• [4]Rusch VW, Asamura H, Watanabe H, Giroux DJ, Rami-Porta R, Goldstraw P, Members of IASLC Staging Committee: The IASLC lung cancer staging project: a proposal for a new international lymph node map in the forthcoming seventh edition of the TNM classification for lung cancer. J ThoracOncol 2009, l4:568-577.
• [5]Bhattacharyya N: Contemporary staging and prognosis for primary tracheal malignancies: a population-based analysis. Otolaryngol Head Neck Surg 2004, 131:639-642.
• [6]Smetana HF, Iverson L, Swan LL: Bronchogenic carcinoma. Analysis of 100 autopsy cases. MilSurg 1952, 3:335-351.
• [7]Liebow AA: Tumors of the lower respiratory tract. In Atlas of Tumor Pathology. Washington, DC: Armed Forces Institute of Pathology; 1952:26-53.
• [8]Spencer H: Bronchial mucous gland tumours. Virchows Arch A PatholAnatHistol 1979, 383:101-115.
• [9]Colby TV, Koss MN, Travis WD: Tumors of salivary gland type. In Tumors of the Lower Respiratory Tract: AFIP Atlas of Tumor Pathology. Edited by Rosai J. Washington, DC: American Registry of Pathology; 1995:65-89. [3rd series,Vol. 13]
• [10]Nakagawara A, Ikeda K, Ohgami H: Mucoepidermoid tumor of the bronchus in an infant. J PediatrSurg 1979, 14:608-609.
• [11]Yang CS, Kuo KT, Chou TY, Lin CM, Hsu WH, Huang MH, Wang LS: Mucoepidermoid tumors of the lung: analysis of 11 cases. J Chin Med Assoc 2004, 67:565-570.
• [12]Brandwein MS, Ivanov K, Wallace DI, Hille JJ, Wang B, Fahmy A, Bodian C, Urken ML, Gnepp DR, Huvos A, Lumerman H, Mills SE: Mucoepidermoid carcinoma: a clinicopathologic study of 80 patients with special reference to histological grading. Am J SurgPathol 2001, 25:835-845.
• [13]Heitmiller RF, Mathisen DJ, Ferry JA, Mark EJ, Grillo HC: Mucoepidermoid lung tumors. Ann ThoracSurg 1989, 47:394-399.
• [14]Chin CH, Huang CC, Lin MC, Chao TY, Liu SF: Prognostic factors of tracheobronchial mucoepidermoid carcinoma-15 years experience. Respirology 2008, 13:275-280.
• [15]Barsky SH, Martin SE, Matthews M, Gazdar A, Costa JC: “Low grade” mucoepidermoid carcinoma of the bronchus with “high grade” biological behavior. Cancer 1983, 51:1505-1509.
• [16]Yousem SA, Hochholzer L: Mucoepidermoid tumors of the lung. Cancer 1987, 60:1346-1352.
• [17]Conlan AA, Payne WS, Woolner LB, Sanderson DR: Adenoid cystic carcinoma (cylindroma) and mucoepidermoid carcinoma of the bronchus. Factors affecting survival. J ThoracCardiovascSurg 1978, 76:369-377.