Novel association between TGFA, TGFB1, IRF1, PTGS2 and IKBKB single-nucleotide polymorphisms and occurrence, severity and treatment response of major depressive disorder

PeerJ

article

Katarzyna Bialek¹  Piotr Czarny²  Cezary Watala³  Paulina Wigner¹  Monika Talarowska⁴  Piotr Galecki⁵  Janusz Szemraj²  Tomasz Sliwinski¹ 

[1] Laboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz;Department of Medical Biochemistry, Medical University of Lodz;Department of Haemostatic Disorders, Medical University of Lodz;Institute of Psychology, Department of Personality and Individual Differences, University of Lodz;Department of Adult Psychiatry, Medical University of Lodz

关键词: Major depressive disorder;    Depression;    Inflammation;    Cytokines;    Single nucleotide polymorphism;   

DOI  :  10.7717/peerj.8676

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Background G-TGFB1A-IRFG-PTGS2T-PTGS2A-TGFAT–IKBKB (rs5029748). Methods A total of 360 (180 patients and 180 controls) DNA samples were genotyped using TaqMan probes. Results We observed that A/G of the rs2166975 TGFA, A/C of rs2070729 IRF1 and G/T of rs5029748 IKBKB were associated with an increased risk of depression development while the T/T of rs5029748 IKBKB, T/T of rs4648308 PTGS2 and G/G of rs2166975 TGFA reduced this risk. We also stratified the study group according to gender and found that genotype A/G and allele G of the rs2166975 TGFA, G/T of rs5029748 IKBKB as well as C allele of rs4648308 PTGS2, homozygote A/A and allele A of rs5275 PTGS2 were associated with increased risk of depression development in men while homozygote G/G of rs5275 PTGS2 decreased this risk. Moreover, C/T of rs4648308 PTGS2 and A/G of rs5275 PTGS2 was positively correlated with the risk of the disease occurrence in women. Furthermore, a gene–gene analysis revealed a link between studied polymorphisms and depression. In addition, A/A of rs1800469 TGFB1 was associated with earlier age of onset of the disease while G/G of this SNP increased severity of the depressive episode. Interestingly, A/C of rs2070729 IRF1 and T/T of rs5029748 IKBKB may modulate the effectiveness of selective serotonin reuptake inhibitors therapy. In conclusion, studied SNPs may modulate the risk of occurrence, age of onset, severity of the disease and response to the antidepressant treatment.

【 授权许可】

CC BY