Mutation density changes in SARS-CoV-2 are related to the pandemic stage but to a lesser extent in the dominant strain with mutations in spike and RdRp

PeerJ

article

Doğa Eskier¹  Aslı Suner³  Gökhan Karakülah¹  Yavuz Oktay¹ 

[1] Izmir International Biomedicine and Genome Institute ,(iBG-İzmir), Dokuz Eylül University;Izmir Biomedicine and Genome Center;Department of Biostatistics and Medical Informatics, Faculty of Medicine, Ege University;Faculty of Medicine, Department of Medical Biology, Dokuz Eylül University

关键词: SARS-CoV-2;    COVID-19;    Surface glycoprotein;    Spike;    RNA-dependent RNA polymerase;    RdRp;    Mutation density;   

DOI  :  10.7717/peerj.9703

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

G mutations. Although these differences were not limited to a few hotspots, it is intriguing that the MDe increase is most evident in two critical genes, S and Orf1ab, which are also the genes that harbor the defining mutations of the MT genotype. The nature of these unexpected relationships warrants further research.

【 授权许可】

CC BY