Definition and review on a category of long non-coding RNA: Atherosclerosis-associated circulating lncRNA (ASCLncRNA)

PeerJ

article

Shanshan Lu¹  Qin Liang¹  Yanqing Huang¹  Fanming Meng²  Junwen Liu¹ 

[1] Department of Histology and Embryology, School of Basic Medical Science, Central South University, Changsha, Hunan Province;Department of Parasitology, School of Basic Medical Science, Central South University, Changsha, Hunan Province;China-Africa Research Center of Infectious Diseases, School of Basic Medical Sciences, Central South University, Changsha, Hunan Province

关键词: Atherosclerosis;    Biomarker;    Circulating lncRNAs;    Non-invasive diagnosis;   

DOI  :  10.7717/peerj.10001

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Atherosclerosis (AS) is one of the most common cardiovascular system diseases which seriously affects public health in modern society. Finding potential biomarkers in the complicated pathological progression of AS is of great significance for the prevention and treatment of AS. Studies have shown that long noncoding RNAs (lncRNAs) can be widely involved in the regulation of many physiological processes, and have important roles in different stages of AS formation. LncRNAs can be secreted into the circulatory system through exosomes, microvesicles, and apoptotic bodies. Recently, increasing studies have been focused on the relationships between circulating lncRNAs and AS development. The lncRNAs in circulating blood are expected to be new non-invasive diagnostic markers for monitoring the progression of AS. We briefly reviewed the previously reported lncRNA transcripts which related to AS development and detectable in circulating blood, including ANRIL, SENCR, CoroMarker, LIPCAR, HIF1α-AS1, LncRNA H19, APPAT, KCNQ1OT1, LncPPARδ, LincRNA-p21, MALAT1, MIAT, and UCA1. Further researches and a definition of atherosclerosis-associated circulating lncRNA (ASCLncRNA) were also discussed.

【 授权许可】

CC BY