Development and validation of ferroptosis-related lncRNAs signature for hepatocellular carcinoma

PeerJ

article

Jiaying Liang¹  Yaofeng Zhi¹  Wenhui Deng³  Weige Zhou¹  Xuejun Li¹  Zheyou Cai¹  Zhijian Zhu¹  Jinxiang Zeng¹  Wanlan Wu¹  Ying Dong¹  Jin Huang⁴  Yuzhuo Zhang¹  Shichao Xu¹  Yixin Feng¹  Fuping Ding⁵  Jin Zhang¹ 

[1] Guangzhou University of Chinese Medicine, School of Basic Medical Sciences;Guangzhou University of Chinese Medicine, Research Center of Integrative Medicine, School of Basic Medical Sciences;Guangzhou University of Chinese Medicine, The fourth Affiliated Hospital of Guangzhou University of Chinese Medicine;Guangzhou University of Chinese Medicine, Clinic of Guangzhou University of Chinese Medicine;Guangzhou University of Chinese Medicine, School of Nursing

关键词: Hepatocellular carcinoma;    Ferroptosis;    Immunotherapy;    lncRNA;    Gene signature;   

DOI  :  10.7717/peerj.11627

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

BackgroundHepatocellular carcinoma (HCC) with high heterogeneity is one of the most frequent malignant tumors throughout the world. However, there is no research to establish a ferroptosis-related lncRNAs (FRlncRNAs) signature for the patients with HCC. Therefore, this study was designed to establish a novel FRlncRNAs signature to predict the survival of patients with HCC.MethodThe expression profiles of lncRNAs were acquired from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) database. FRlncRNAs co-expressed with ferroptosis-related genes were utilized to establish a signature. Cox regression was used to construct a novel three FRlncRNAs signature in the TCGA cohort, which was verified in the GEO validation cohort.ResultsThree differently expressed FRlncRNAs significantly associated with prognosis of HCC were identified, which composed a novel FRlncRNAs signature. According to the FRlncRNAs signature, the patients with HCC could be divided into low- and high-risk groups. Patients with HCC in the high-risk group displayed shorter overall survival (OS) contrasted with those in the low-risk group (P < 0.001 in TCGA cohort and P 1, P  1, P < 0.05). Meanwhile, it was also a useful tool in predicting survival among each stratum of gender, age, grade, stage, and etiology,etc. This signature was connected with immune cell infiltration (i.e., Macrophage, Myeloid dendritic cell, and Neutrophil cell, etc.) and immune checkpoint blockade targets (PD-1, CTLA-4, and TIM-3).ConclusionThe three FRlncRNAs might be potential therapeutic targets for patients, and their signature could be utilized for prognostic prediction in HCC.

【 授权许可】

CC BY