SIKVAV peptide functionalized ultra-small gold nanoparticles for selective targeting of α6β1 integrin in hepatocellular carcinoma

Applied Nanotechnology and Nanoscience International Conference 2016

Roskamp, M.^1 ; Coulter, T.^1 ; Ding, Y.^1 ; Perrins, R.^1 ; Espinosa Garcia, C.^1 ; Pace, A.^1 ; Hale, S.^1 ; Robinson, A.^1 ; Williams, P.^1 ; Aguilera Peral, U.^1 ; Patel, K.^1 ; Palmer, D.^1

Midatech Pharma PLC, Abingdon, United Kingdom^1

关键词: Hepatocellular carcinoma;    In-vitro assays;    Integrin binding;    Ligand exchanges;    Nanoparticle biodistribution;    Nanoparticle surface;    Pharmacokinetic studies;    Targeted nanoparticle;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/829/1/012017/pdf
DOI  :  10.1088/1742-6596/829/1/012017

来源: IOP

【 摘 要 】

Ultra-small glycan-passivated gold nanoparticles of -9M). In a rat model, pharmacokinetic studies showed that nanoparticle biodistribution was strongly altered by labelling with either peptide and DM4 moieties.