Anti-inflammatory and antiaging properties of chlorogenic acid on UV-induced fibroblast cell

PeerJ

article

Ermi Girsang¹  Chrismis N. Ginting¹  I Nyoman Ehrich Lister¹  Kamila yashfa Gunawan²  Wahyu Widowati³ 

[1] Faculty of Medicine, Universitas Prima Indonesia;Biomolecular and Biomedical Research Center;Faculty of Medicine, Maranatha Christian University

关键词: Antiaging;    Anti-inflammatory;    Apoptosis;    Chlorogenic acid;    Ultraviolet;   

DOI  :  10.7717/peerj.11419

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Background Skin aging is the most common dermatological problem caused by intrinsic and extrinsic factor, such as exposure to (ultraviolet) UV rays. Chlorogenic acid (CA) is a phenolic compound which is known for its antioxidant properties against oxidative stress. Objective This study investigates the antiaging and anti-inflammatory properties of CA on UV-induced skin fibroblast cells. Methods Anti-inflammatory properties of CA were assessed by measuring inflammatory-related proteins IL-1β and TNF-α, while antiaging properties of CA were assessed by measuring reactive oxygen species (ROS), apoptosis, live and necrotic cells, and COL-3 gene expression level. Results Treating UV-induced skin fibroblast cells with CA decreased the level of ROS, IL-1β, TNF-α, apoptotic cells, and necrotic cells and increased live cells and COL-3 gene expression. Conclusion CA has the potential as the protective compound against inflammation and aging by decreasing the level ROS, pro-inflammatory cytokines IL-1β and TNF-α, apoptotic cells, and necrotic cells and by increasing live cells and COL-3 gene expression.

【 授权许可】

CC BY