The characteristics and roles of antimicrobial peptides as potential treatment for antibiotic-resistant pathogens: a review

PeerJ

article

Nurul Hana Zainal Baharin¹  Nur Fadhilah Khairil Mokhtar²  Mohd Nasir Mohd Desa¹  Banulata Gopalsamy¹  Nor Nadiha Mohd Zaki²  Mohd Hafis Yuswan²  AbdulRahman Muthanna¹  Nurul Diana Dzaraly¹  Sahar Abbasiliasi²  Amalia Mohd Hashim²  Muhamad Shirwan Abdullah Sani⁴  Shuhaimi Mustafa³ 

[1] Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia;Laboratory of Halal Science Research, Halal Products Research Institute, Universiti Putra Malaysia;Department of Microbiology, Faculty of Biotechnology and Biomolecular Science, Universiti Putra Malaysia;International Institute for Halal Research and Training ,(INHART), International Islamic University Malaysia

关键词: Antibiotic resistance;    Antimicrobial peptides;    AMPs;    Bacteriocins;    Bacterial resistance;    Mechanisms of action;    Naturally Occurring AMPs;    Synthetic AMPs;   

DOI  :  10.7717/peerj.12193

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

The emergence of antibiotic-resistant bacteria has become a significant and ever-increasing threat to global public health, increasing both morbidity and mortality rates, and the financial burden on health services. Infection by drug-resistant bacteria is anticipated to contribute to the demise of almost 10 million people by the year 2050 unless a competent and effective response is devised to engage with this issue. The emergence and spread of resistance are commonly caused by the excessive or inappropriate use of antibiotics and substandard pharmaceuticals. It arises when pathogens adapt to different conditions and develop self-defence mechanisms. Currently, novel antimicrobial peptides (AMPs) have been reported to be the sole cure for some clinical cases of infectious diseases such as sepsis and skin infections, although these agents may, on occasion, require administration together with an adjunctive low-dose antibiotic. Although AMPs are a promising alternative form of anti-microbial therapy and easily applied in the medical sector, they still have limitations that should not be taken lightly. Hence, this review explores the characteristics, advantages and disadvantages of AMPs for their potential in treating antibiotic-resistant pathogens.

【 授权许可】

CC BY