The impact of aging and physical training on angiogenesis in the musculoskeletal system

PeerJ

article

Magdalena Zmudzka¹  Jerzy A. Zoladz¹  Joanna Majerczak¹ 

[1] Chair of Exercise Physiology and Muscle Bioenergetics, Faculty of Health Sciences, Jagiellonian University Medical College

关键词: Angiogenesis;    Physical training;    Muscle-bone crosstalk;    Skeletal muscle aging;    Bone aging;    Nitric oxide;    VEGF;    Capillaries;   

DOI  :  10.7717/peerj.14228

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Angiogenesis is the physiological process of capillary growth. It is strictly regulated by the balanced activity of agents that promote the formation of capillaries (pro-angiogenic factors) on the one hand and inhibit their growth on the other hand (anti-angiogenic factors). Capillary rarefaction and insufficient angiogenesis are some of the main causes that limit blood flow during aging, whereas physical training is a potent non-pharmacological method to intensify capillary growth in the musculoskeletal system. The main purpose of this study is to present the current state of knowledge concerning the key signalling molecules implicated in the regulation of skeletal muscle and bone angiogenesis during aging and physical training.

【 授权许可】

CC BY