Chemical composition, antioxidant and anti-inflammatory properties of Monarda didyma L. essential oil

PeerJ

article

Daniele Fraternale¹  Hanh Dufat²  Maria Cristina Albertini¹  Chouaha Bouzidi²  Rossella D’Adderio¹  Sofia Coppari¹  Barbara Di Giacomo¹  Davide Melandri³  Seeram Ramakrishna⁴  Mariastella Colomba¹ 

[1] Department of Biomolecular Sciences, University of Urbino;Produits Naturels, Analyse et Synthèse, CITCOM-UMR CNRS 8038—Faculté de Santé, Pharmacie, Université Paris Cité, Université de Paris;U. Burns Center, Dermatology and Emilia Romagna Regional Skin Bank, M. Bufalini Hospital;Center for Nanofibers and Nanotechnology, National University of Singapore

关键词: Scarlet beebalm;    Monoterpenes;    Monoterpenoids;    LPS;    microRNAs;    TLR-4;   

DOI  :  10.7717/peerj.14433

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

In the present study, Monarda didyma L. essential oil (isolated from the flowering aerial parts of the plant) was examined to characterize its chemotype and to evaluate, in addition to the quali-quantitative chemical analysis, the associated antioxidant and anti-inflammatory activities. The plants were grown in central Italy, Urbino (PU), Marche region. Different analyses (TLC, GC-FID, GC-MS and 1H-NMR) allowed the identification of twenty compounds among which carvacrol, p-cymene and thymol were the most abundant. On this basis, the chemotype examined in the present study was indicated as Monarda didyma ct. carvacrol. The antioxidant effect was assessed by DPPH assay. Moreover, this chemotype was investigated for the anti-inflammatory effect in an in vitro setting (i.e., LPS-stimulated U937 cells). The decreased expression of pro-inflammatory cytokine IL-6 and the increased expression of miR-146a are suggestive of the involvement of the Toll-like receptor-4 signaling pathway. Although further studies are needed to better investigate the action mechanism/s underlying the results observed in the experimental setting, our findings show that M. didyma essential oil is rich in bioactive compounds (mainly aromatic monoterpenes and phenolic monoterpenes) which are most likely responsible for its beneficial effect.

【 授权许可】

CC BY