Serratia marcescens antibiotic resistance mechanisms of an opportunistic pathogen: a literature review

PeerJ

article

Faviola Tavares-Carreon¹  Karla De Anda-Mora²  Idalia C. Rojas-Barrera³  Angel Andrade² 

[1] Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León;Departamento de Microbiología, Facultad de Medicina, Universidad Autónoma de Nuevo León;Environmental Genomics Group, Max Planck Institute for Evolutionary Biology;Christian-Albrechts-University Kiel

关键词: Serratia marcescens;    Opportunistic pathogen;    Intrinsic resistance;    Acquired resistance;    Antimicrobial resistance;   

DOI  :  10.7717/peerj.14399

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Serratia marcescens is a ubiquitous bacterium from order Enterobacterales displaying a high genetic plasticity that allows it to adapt and persist in multiple niches including soil, water, plants, and nosocomial environments. Recently, S. marcescens has gained attention as an emerging pathogen worldwide, provoking infections and outbreaks in debilitated individuals, particularly newborns and patients in intensive care units. S. marcescens isolates recovered from clinical settings are frequently described as multidrug resistant. High levels of antibiotic resistance across Serratia species are a consequence of the combined activity of intrinsic, acquired, and adaptive resistance elements. In this review, we will discuss recent advances in the understanding of mechanisms guiding resistance in this opportunistic pathogen.

【 授权许可】

CC BY