Models of ultrasonic radiomics and clinical characters for lymph node metastasis assessment in thyroid cancer: a retrospective study

PeerJ

article

Hui Zhu¹  Bing Yu²  Yanyan Li¹  Yuhua Zhang¹  Juebin Jin³  Yao Ai²  Xiance Jin²  Yan Yang¹ 

[1] Department of Ultrasound, the Second Affiliated Hospital of Wenzhou Medical University;Department of Radiotherapy Center, The 1st Affiliated Hospital of Wenzhou Medical University;Department of Medical Engineering, The 1st Affiliated Hospital of Wenzhou Medical University

关键词: Ultrasound;    Radiomics;    Machine learning;    Lymph node metastasis;    Papillary thyroid carcinoma;   

DOI  :  10.7717/peerj.14546

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

BackgroundPreoperative prediction of cervical lymph node metastasis in papillary thyroid carcinoma provided a basis for tumor staging and treatment decision. This study aimed to investigate the utility of machine learning and develop different models to preoperatively predict cervical lymph node metastasis based on ultrasonic radiomic features and clinical characteristics in papillary thyroid carcinoma nodules.MethodsData from 400 papillary thyroid carcinoma nodules were included and divided into training and validation group. With the help of machine learning, clinical characteristics and ultrasonic radiomic features were extracted and selected using randomforest and least absolute shrinkage and selection operator regression before classified by five classifiers. Finally, 10 models were built and their area under the receiver operating characteristic curve, accuracy, sensitivity, specificity, positive predictive value and negative predictive value were measured.ResultsAmong the 10 models, RF-RF model revealed the highest area under curve (0.812) and accuracy (0.7542) in validation group. The top 10 variables of it included age, seven textural features, one shape feature and one first-order feature, in which eight were high-dimensional features.ConclusionsRF-RF model showed the best predictive performance for cervical lymph node metastasis. And the importance features selected by it highlighted the unique role of higher-dimensional statistical methods for radiomics analysis.

【 授权许可】

CC BY