Association between coronary artery disease and incident cancer risk: a systematic review and meta-analysis of cohort studies

PeerJ

article

Hsin-Hao Chen¹  Yi-Chi Lo⁴  Wei-Sheng Pan⁴  Shu-Jung Liu⁵  Tzu-Lin Yeh¹  Lawrence Yu-Min Liu² 

[1] Department of Family Medicine, Hsinchu MacKay Memorial Hospital, Hsinchu City;MacKay Junior College of Medicine, Nursing, and Management;Department of Medicine, MacKay Medical College;Department of Medical Education and Research, Hsinchu MacKay Memorial Hospital, Hsinchu City;Department of Medical Library, MacKay Memorial Hospital, Tamsui Branch;Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University;Division of Cardiology, Department of Internal Medicine, Hsinchu MacKay Memorial Hospital, Hsinchu City

关键词: Cancer;    Cohort;    Coronary artery disease;    Meta-analysis;    Systematic review;   

DOI  :  10.7717/peerj.14922

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Objective Coronary artery disease (CAD) and cancer are the two leading causes of death worldwide. Evidence suggests the existence of shared mechanisms for these two diseases. We aimed to conduct a systematic review and meta-analysis to investigateassociation between CAD and incident cancer risk. Methods We searched Cochrane, PubMed, and Embase from inception until October 20, 2021, without language restrictions. Observational cohort studies were used to investigate the association between CAD and incident cancer risk. Using random-effects models, the odds ratio (OR) and 95% confidence interval (CI) were calculated. We utilized subgroup and sensitivity analyses to determine the potential sources of heterogeneity and explore the association between CAD and specific cancers. This study was conducted under a pre-established, registered protocol on PROSPERO (CRD42022302507). Results We initially examined 8,533 articles, and included 14 cohort studies in our review, 11 of which were eligible for meta-analysis. Patients with CAD had significantly higher odds of cancer risk than those without CAD (OR = 1.15, 95% CI = [1.08–1.22], I21 year of follow-up (OR = 1.23, 95% CI = [1.08–1.39], I2 = 76%). Regarding the specific outcome, the incident risk for colorectal and lung cancers was significantly higher (OR = 1.06, 95% CI = [1.03–1.10], I2 = 10%, and OR = 1.36, 95% CI = [1.15–1.60], I2 = 90%, respectively) and that for breast cancer was lower (OR = 0.86, 95% CI = [0.77–0.97], I2 = 57%) in patients with CAD than in those without CAD. Conclusion CAD may be associated with incident cancer risk, particularly for lung and colorectal cancers, in men and women as well as patients with or without myocardial infarction. Early detection of new-onset cancer and detailed cancer surveillance programs should be implemented in patients with CAD to reduce cancer-related morbidity and mortality.

【 授权许可】

CC BY