Effects of ambient temperature on atopic dermatitis and attributable health burden: a 6-year time-series study in Chengdu, China

PeerJ

article

Zerong Chen¹  Mengmeng Li¹  Tianjiao Lan³  Yiyi Wang¹  Xingli Zhou¹  Wei Dong⁴  Gong Cheng⁵  Wei Li¹  Liangliang Cheng⁶ 

[1] Department of Dermatovenereology, Rare Disease Center, West China Hospital, Sichuan University;MRC Biostatistics Unit, University of Cambridge;West China School of Public Health, Sichuan University;School of Atmospheric Sciences, Nanjing University of Information Science and Technology;Department of Geriatrics, Gansu Provincial Hospital;School of Public Health, Sun Yat-sen University

关键词: Atopic dermatitis;    Temperature;    Attributable burden;    Climate change;   

DOI  :  10.7717/peerj.15209

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

BackgroundDespite increasing public concerns about the widespread health effects of climate change, the impacts of ambient temperature on atopic dermatitis (AD) remain poorly understood.ObjectivesWe aimed to explore the effect of ambient temperature on AD and to estimate the burdens of AD attributed to extreme temperature.MethodsData on outpatients with AD and climate conditions in Chengdu, China were collected. A distributed lag nonlinear model (DLNM) was adopted to explore the association between daily mean temperature and AD outpatient visits. Subgroup analysis was used to identify vulnerable populations. Attributable burden was estimated by the epidemiological attributable method.ResultsWe analyzed 10,747 outpatient visits from AD patients at West China Hospital in Chengdu between January 1, 2015, and December 31, 2020. Both low (25.3 °C) were associated with increased AD outpatient visits, with the increase being more pronounced at low temperature, as evidenced by a 160% increase in visits when the temperature dropped below zero from the minimum mortality temperature (22.8 °C). Children and males were the most susceptible populations. Approximately 25.4% of AD outpatient visits were associated with temperatures, causing an excessive 137161.5 US dollars of health care expenditures during this 6-year period.ConclusionsBoth high and low temperatures, particularly low temperatures, were significantly associated with an increased risk of AD, with children and males showing the strongest associations. Extreme environmental temperature has been identified as one of the major factors promoting the development of AD. However, individual patient-level exposures still needed to be investigated in future studies to confirm the causality between temperature and AD.

【 授权许可】

CC BY