EDIL3 is a potential prognostic biomarker that correlates with immune infiltrates in gastric cancer

PeerJ

article

Bin Ke¹  Zheng-Kai Liang²  Bin Li¹  Xue-Jun Wang¹  Ning Liu¹  Han Liang¹  Ru-Peng Zhang¹ 

[1] Department of Gastric Surgery, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy;Department of Gastrointestinal Surgery, Liaocheng People’s Hospital

关键词: EDIL3;    Gastric cancer;    Prognosis;    Expression;    Immune infiltration;   

DOI  :  10.7717/peerj.15559

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

BackgroundEDIL3, which contains epidermal growth factor-like repeats and discoidin I-like domains, is a secretory protein that plays an important role in embryonic development and various illnesses. However, the biological function of EDIL3 in gastric cancer (GC) is still unclear. The objective of this research was to explore the role and potential mechanism of EDIL3 in GC.MethodsIn this study, we used the GEPIA, HPA, MethSurv, SMART, STRING, GeneMANIA, LinkedOmics TIMER, TIMER2.0, TISIDB, and RNAactDrug databases to comprehensively analyze the roles of EDIL3 in GC. To validate the in silico findings, EDIL3 expression was measured in our collected GC tissues. Meanwhile, several in vitro experiments were performed to test the function of EDIL3 in GC.ResultsWe found that EDIL3 was highly expressed in GC and associated with adverse clinical features. In vitro assays revealed that EDIL3 promoted the proliferation, migration, and invasion of GC cells. The functions of EDIL3 and co-expression genes were significantly associated with extracellular structure organization and matrix receptor interaction. EDIL3 expression was positively associated with numerous tumor-infiltrating immune cells and their biomarkers.ConclusionThis study determined that EDIL3 may function as an oncogene and is associated with immune infiltration in GC. EDIL3 could be used as a potential therapeutic target for GC.

【 授权许可】

CC BY