CD44 but not CD24 expression is related to poor prognosis in non-cardia adenocarcinoma of the stomach

BMC Gastroenterology

Research Article

Xueyuan Cao¹  Zhifang Jia²  Jing Jiang²  Donghui Cao²  Fei Kong²  Hongxi Ma³  Yinping Wang³  MeiShan Jin³ 

[1]Department of Gastric and Colorectal Surgery, First Hospital of Jilin University, 130021, Changchun, Jilin, China

[2]Division of Clinical Epidemiology, First Hospital of Jilin University, 130021, Changchun, Jilin, China

[3]Division of Pathology, First Hospital of Jilin University, 130021, Changchun, Jilin, China

关键词: CD44;    CD24;    Prognosis;    Gastric cancer;    Expression;    Helicobacter pylori;   

DOI  :  10.1186/1471-230X-14-157

 received in 2014-01-31, accepted in 2014-09-09,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundRecent studies have focused on the diagnostic and prognostic significance of CD24 and CD44 expression in human cancers. This study aimed to explore changes in CD44 and CD24 expression levels in patients with gastric cancer and to assess their prognostic values.MethodsCD44 and CD24 expression levels were investigated immunohistochemically in tumor samples from 290 patients with non-cardia gastric adenocarcinoma, of whom 77 had paired adjacent normal gastric mucosa. CD24 and CD44 mRNA levels were determined by quantitative polymerase chain reaction in 34 patients. Serum anti-Helicobacter pylori IgG was detected by enzyme-linked immunosorbent assay. Relationships between CD44 and CD24 protein expression levels and tumor parameters were analyzed and their prognostic values were evaluated by Cox proportional hazards models.ResultsCD24 and CD44 expression levels were significantly higher in patients with gastric cancer compared with those in paired controls (45.5% vs. 0.0%, and 61.0% vs. 0.0%, P < 0.001). Among 290 patients, the overall survival rate was significantly higher in CD44(−) compared with CD44(+) patients (log-rank test, P = 0.035). However, there was no significant correlation between CD24 expression and overall survival time (log-rank test, P = 0.115). Multivariate regression analysis indicated that positive CD44 expression (P = 0.029), TNM staging (P < 0.001), and lymphovascular invasion (P = 0.016), but not CD24 expression (P = 0.065), were independent prognostic factors in gastric cancer.ConclusionsIndividual expression of CD44 was associated with poor survival in patients with gastric carcinoma.

【 授权许可】

Unknown   
© Cao et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.