A review of the pathological mechanisms and clinical implications of coagulopathy in COVID-19

Journal of Applied Hematology

article

Suvir Singh¹  Kunal Jain¹  Davinder Paul¹  Jagdeep Singh¹ 

[1] Department of Clinical Hematology and Stem Cell Transplantation, Dayanand Medical College

关键词: Anticoagulation;    coagulation;    coagulopathy;    COVID-19;    cytokines;    hematology;    thrombosis;   

DOI  :  10.4103/joah.joah_19_21

学科分类：社会科学、人文和艺术（综合）

来源: Medknow

【 摘 要 】

Coronavirus disease-19 (COVID-19) is an ongoing global pandemic with approximately 15% of patients requiring mechanical ventilation and intensive care unit care. The mechanisms of end-organ damage and mortality in severe COVID are slowly being unraveled. COVID-related coagulopathy is a characteristic syndrome that plays a key role in multi-organ dysfunction and severe disease. Mechanistically, many components including endothelial cells, the coagulation system, complement system, cytokines, and NETosis are involved in the pathogenesis of this syndrome and provide potential therapeutic targets. We provide a focused review on the current understanding of COVID-19-related coagulopathy and its therapeutic implications.

【 授权许可】

CC BY-NC-SA