Thrombosis and coagulopathy in COVID‐19: An illustrated review

Research and Practice in Thrombosis and Haemostasis

Marcel Levi¹  Beverley J. Hunt² 

[1] Department of Medicine and Cardiometabolic Programme‐NIHR UCLH/UCL BRC University College London Hospitals NHS Foundation Trust London UK;Thrombosis & Haemophilia Centre Guys & St Thomas NHS Foundation Trust London UK;

关键词: COVID‐19;    novel coronavirus;    thrombosis;    coagulopathy;    coagulation;   

DOI  :  10.1002/rth2.12400

来源: DOAJ

【 摘 要 】

Abstract This illustrated review discusses the haemostatic changes seen in patients with severe coronavirus disease 2019 (COVID‐19) infection and their possible causes. We discuss the crosstalk between inflammation and coagulation resulting in high levels of acute‐phase proteins, very high levels of D‐dimers, and absence of disseminated intravascular coagulation seen in patients with severe COVID‐19. There appear to be high rates of venous thromboembolism and also, what has been poorly described before in acute lung injury, a high rate of pulmonary immunothrombosis (thrombosis secondary to inflammation).

【 授权许可】

Unknown