Role of platelet rich plasma in osteoarthritis of the knee joint

Medical Journal of Babylon

article

Samer Mohammed Redah¹ 

[1] Alwasity Teaching Hospital

关键词: Knee joint;    osteoarthritis;    platelet rich plasma;    role;   

DOI  :  10.4103/MJBL.MJBL_9_22

学科分类：社会科学、人文和艺术（综合）

来源: Wolters Kluwer Medknow Publications

【 摘 要 】

Background: Osteoarthritis (OA) is a leading cause of disability and doubles the number of visits to primary care practitioners for those with the condition in comparison to those without. OA affects the knee more often than any other joint, Platelet-rich plasma (PRP) is a concentrate of autologous blood growth factors which has been shown to provide some symptomatic relief in early osteoarthritis (OA) of the knee. Objective: the aim of this prospective study is to demonstrate the effectiveness of prp injection in patients with OA of the knee. Materials and Methods: 60 patients with 74 knees affected by variable grades of OA were enrolled in our study in Alwasity teaching hospital from January 2018 to December 2019 with follow up till December 2021. 49 patients with 62 knees were females and 11 patients with 12 knees were males, all patients received three injections of prp at weekly intervals and were followed up every three months for two years. Results: After one year of follow up 11 knees with KL-G I had decrease in VAS score to 0–2 (73.3%),19 knees with KL-G II had decrease of VAS score to 1–3 (70.3%),10 knees with KL-G III had decrease of VAS score to 4–5 (40%), All 7 knees with KL-G IV didn’t have any response during treatment or at the end of 1 st year. All patients had scores similar to that before starting treatment at the end of 2 nd year. Conclusion: The present state of knowledge holds promise for PRP of certain specifications for pain management in early OA knee. PRP has consistently been shown by various clinical studies to be useful in OA of the knee. Nevertheless, a lot of grey areas remain in our understanding of PRP and OA, and many more focused clinical and in vitro studies are required. PRP seems to be an evolving future trend.

【 授权许可】

CC BY-NC-SA