Objective Comparison between Platelet Rich Plasma Alone and in Combination with Physical Therapy in Dogs with Osteoarthritis Caused by Hip Dysplasia

Animals

JoséMaría Carrillo¹  AylaDel Romero¹  JoaquínJesús Sopena¹  Belén Cuervo¹  Elena Damiá¹  Deborah Chicharro¹  Mónica Rubio¹  JoséManuel Vilar²  Angelo Santana³  JoséJoaquín Cerón⁴ 

[1] Bioregenerative Medicine and Applied Surgery Research Group, Departamento de medicina y cirugía animal, Facultad de veterinaria, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Valencia, Spain;Department of Animal Pathology, Instituto Universitario de Investigaciones Biomédicas y Universitarias, Universidad de Las Palmas de Gran Canaria, 35416 Trasmontaña S/N. Arucas, Spain;Department of Mathematics, Universidad de Las Palmas de Gran Canaria, Campus de Tafira, 35018 Las Palmas, Spain;García Cugat Foundation CEU-UCH Chair of Medicine and Regenerative Surgery, 08006 Barcelona, Spain;

关键词: plasma rich in growth factors;    platelet rich plasma;    osteoarthritis;    canine;    physical therapy;    biomarkers;   

DOI  :  10.3390/ani10020175

来源: DOAJ

【 摘 要 】

Osteoarthritis (OA) is one of the most significant joint diseases worldwide. There are different therapies for OA treatment, and a relatively new strategy is the use of plasma rich in growth factors (PRGF), a platelet rich plasma (PRP) derivative. The objective of this study was to objectively assess the efficacy and duration of the effect of an intraarticular injection of PRGF and a combination of PRGF + physical therapy. The objective assessment was provided using a force platform. The obtained parameters were peak vertical force (PVF) and vertical impulse (VI). A total of 24 dogs with lameness and pain associated to OA attributable to bilateral hip dysplasia were included in the study. Animals were divided into two study groups and evaluated at baseline and at 30, 90, and 180 days after intraarticular PRGF or PRGF + physical therapy. Significant differences were observed at every checkpoint with respect to basal time in both groups. However, after 180 days, the PRGF group showed a decrease in PVF and VI with respect to the values obtained at 90 days. However, the PRGF + physical therapy group maintained increased values of both PVF and VI values during the 180-day study period.

【 授权许可】

Unknown