Efficacy of various proton-pump inhibitors and calcium hydroxide as intracanal medicaments against Enterococcus Faecalis : An in vitro study

Endodontology

article

Koparkar, Tejas¹  Kalyan, Sai²  Mandke, Lalitagauri¹  Vandekar, Mansi¹ 

[1] Department of Conservative Dentistry and Endodontics, D. Y. Patil School of Dentistry;Department of Conservative Dentistry and Endodontics, Terna Dental College

关键词: Calcium hydroxide;    Enterococcus faecalis;    intracanal medicament;    proton-pump inhibitors;    recurrent endodontic infection;   

DOI  :  10.4103/endo.endo_102_22

学科分类：材料科学（综合）

来源: Wolters Kluwer Medknow Publications

【 摘 要 】

Aim:  The purpose of this study was to compare the efficacy of four proton-pump inhibitors (PPIs) (pantoprazole, omeprazole, lansoprazole, and rabeprazole) when combined with calcium hydroxide and used as intracanal medicaments against Enterococcus faecalis. Methods:  A total of 550 microliters of E. faecalis strain was inoculated into two mixtures 6.25 μg/ml and 25 μg/ml containing calcium hydroxide (concentration 16 mg/ml) and PPIs (concentration 1 mg/ml). The efficacy was evaluated by comparing the optical density of the mixtures at 630 nm with two time parameters of 18 h and 24 h. Results:  At 18 h, O6 (calcium hydroxide and omeprazole 6.25 μg/ml) showed the maximum percentage inhibition of E. faecalis strain and R25 (calcium hydroxide and rabeprazole 25 μg/ml) showed the least inhibition. At 24-h time interval, O6 showed the maximum inhibition, while R6 (calcium hydroxide and rabeprazole 6.25 μg/ml) showed the least inhibition of E. faecalis strain. Conclusion:  The use of PPIs with calcium hydroxide did show promising results and the combination could be used successfully as an intracanal medicament.

【 授权许可】

CC BY-NC-SA