Neonatal Sepsis – Microbiological Spectrum, Antimicrobial Sensitivity, and Risk Factors for Mortality in Newborn Unit of Rural Teaching Hospital: A Retrospective Study

Medical Journal of Dr. D.Y. Patil Vidyapeeth

article

Poyekar, Subhash Shankar¹ 

[1] Department of Pediatrics, Rural Medical College

关键词: Antibiotics;    bacteria;    multidrug resistance;    neonatal sepsis;    neonate;   

DOI  :  10.4103/mjdrdypu.mjdrdypu_558_20

学科分类：社会科学、人文和艺术（综合）

来源: Wolters Kluwer Medknow Publications

【 摘 要 】

Background:  Neonatal sepsis (NS) is one of the leading cause of neonatal mortality. In order to decrease the morbidity and mortality associated with neonatal sepsis, treating pediatrician/neonatologist should have a keen knowledge of the existing microbiological flora and their drug-susceptibility pattern. Hence, the present study was conducted with the objective to investigate the etiological agents, pattern of antimicribial sensitivity, and risk factors for mortality in neonates with culture-proven neonatal sepsis. Methods:  A retrospective/cross-sectional study was conducted over a period of 24 months in teaching Rural Hospital, Maharashtra, India. Demographic data, type of isolates, and its sensitivity pattern were recorded. Results:  Of the 343 blood samples sent during the study period from neonatal intensive care unit, 84 (24.5%) samples grew organisms. Early-onset sepsis (EOS) occurred in 58.1% of cases. Of the 74 bacterial isolates, 55.4% were Gram-positive organisms and 44.6% were Gram-negative pathogen. Candida species were identified in 11.9% neonates. Staphylococcus aureus (21.6%) and coagulase-negative Staphylococcus (CONS) (21.6%) were predominant Gram-positive pathogen. Klebsiella pneumoniae was the main Gram-negative pathogen (29.7%) followed by pseudomonas (6.76%). Gram-positive organisms (Staphylococcus and CONS) showed maximum sensitivity to vancomycin and linezolid. Survival rate among neonates with culture-positive sepsis was 78.6%. Conclusions:  This study highlights growing resistance to commonly used antibiotics/antifungal agents posing a great threat to neonatal survival and thereby warrants the modification of existing empirical therapy. Implementation of effective preventive strategies to combat the emergence of antibiotic resistance is urgently needed.

【 授权许可】

CC BY-NC-SA