An Agent that can Prohibit Microbial Development and Infection

Christian, A

Lawrence Livermore National Laboratory

关键词: Genes;    59 Basic Biological Sciences;    Antibiotics;    Genetics;   

DOI  :  10.2172/15014667
RP-ID  :  UCRL-TR-209328
RP-ID  :  W-7405-ENG-48
RP-ID  :  15014667

美国|英语

来源: UNT Digital Library

【 摘 要 】

We have developed a process that makes use of double-stranded DNA:RNA hybrids to inhibit specific, targeted genetic activity completely within a cell. This process can be used in both human and bacterial cells. The agent that produces this effect can be inserted into a cell and remain quiescent for a considerable period of time without affecting cellular processes, until the gene against which it is targeted is induced. At this time the agent becomes effective, silencing the genetic response without affecting the host cell in any other way. When given as an anti-infective, this process may have significant use as an anti-bacterial, anti-viral agent. Our objective with this proposal is to develop the siHybrid concept sufficiently that it can be used as both an antibiotic and an antiviral agent.