A chitosan-based hydrogel containing zinc oxide nanoparticles as a carrier for improving antibacterial activity and controlling the release of antibiotics

Micro & nano letters

article

Ali Rastegari¹  Fatemeh Hasanshakir¹  Zohreh Mohammadi¹  Fatemeh Saadatpor²  Homa Faghihi¹  Fatemeh Moraffah³ 

[1] Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Iran University of Medical Sciences;Molecular Virology Lab, Department of Microbiology, School of Biology, College of Science, University of Tehran;Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences

关键词: antibacterial activity;    chitosan;    hydrogel;    nanoparticle;    vancomycin;    zinc oxide;   

DOI  :  10.1049/mna2.12172

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Microbial infections are considered one of the most important concerns of the world community. Developing drug delivery systems based on formulation of nanoparticles (NPs) with antimicrobial agents has shown beneficial effectiveness against microbial infections and related antimicrobial resistance. In this study, the authors prepared and characterized a chitosan-based hydrogel loaded with zinc oxide NPs for controlling the release of vancomycin and also improving its antibacterial effect. Characterization studies demonstrated that the developed biopolymeric hydrogel was able to sustain and control the release of vancomycin in response to acidic media for 96 h. Furthermore, antimicrobial studies showed significant and efficient antibacterial activity of prepared hydrogel against Staphylococcus aureus and Pseudomonas aeruginosa. Based on the obtained results, it can be concluded that the prepared chitosan hydrogel (CH) containing zinc oixde (ZnO) NPs has a desirable activity for controlling the release of vancomycin and improving its antibacterial properties.

【 授权许可】

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