Synthesis and characterization of core-shell Fe3O4-gold-chitosan nanostructure

Journal of Nanobiotechnology

Research

Meisam Sadeghi¹  Kevin Kennedy²  Hossein Salehizadeh³  Elham Hekmatian⁴ 

[1] Biotechnology Engineering Group, University of Isfahan, Isfahan, Iran;Department of Civil Engineering, University of Ottawa, K1N 6N5, Ottawa, ON, Canada;Department of Civil Engineering, University of Ottawa, K1N 6N5, Ottawa, ON, Canada;Biotechnology Engineering Group, University of Isfahan, Isfahan, Iran;Faculty of Medicine, Isfahan University of Medical Science, Isfahan, Iran;

关键词: bioseparation;    core-shell;    FeO-gold-chitosan;    hydrogel;    magnetic;    nanocomposite;    nanoparticle;   

DOI  :  10.1186/1477-3155-10-3

 received in 2011-09-06, accepted in 2012-01-05,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundFe3O4-gold-chitosan core-shell nanostructure can be used in biotechnological and biomedical applications such as magnetic bioseparation, water and wastewater treatment, biodetection and bioimaging, drug delivery, and cancer treatment.ResultsMagnetite nanoparticles with an average size of 9.8 nm in diameter were synthesized using the chemical co-precipitation method. A gold-coated Fe3O4 monotonous core-shell nanostructure was produced with an average size of 15 nm in diameter by glucose reduction of Au3+ which is then stabilized with a chitosan cross linked by formaldehyde. The results of analyses with X-ray diffraction (XRD), Fourier Transformed Infrared Spectroscopy (FTIR), Transmission Electron Microscopy (TEM), and Atomic Force Microscopy (AFM) indicated that the nanoparticles were regularly shaped, and agglomerate-free, with a narrow size distribution.ConclusionsA rapid, mild method for synthesizing Fe3O4-gold nanoparticles using chitosan was investigated. A magnetic core-shell-chitosan nanocomposite, including both the supermagnetic properties of iron oxide and the optical characteristics of colloidal gold nanoparticles, was synthesized.

【 授权许可】

CC BY   
© Salehizadeh et al; licensee BioMed Central Ltd. 2012