Head-to-Head Comparison of 68 Ga-FAPI-46 and 18 F-FDG PET/CT for Evaluation of Head and Neck Squamous Cell Carcinoma: A Single-Center Exploratory Study

The Journal of Nuclear Medicine

article

Chetsadaporn Promteangtrong¹  Dheeratama Siripongsatian¹  Attapon Jantarato¹  Anchisa Kunawudhi¹  Peerapon Kiatkittikul¹  Sukanya Yaset¹  Natphimol Boonkawin¹  Chanisa Chotipanich¹ 

[1] National Cyclotron and PET Centre, Chulabhorn Hospital, Chulabhorn Royal Academy

关键词: FAPI;    FDG;    PET/CT;   

DOI  :  10.2967/jnumed.121.262831

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

68Ga-conjugated fibroblast activation protein inhibitor (68Ga-FAPI) has become an attractive agent for PET. This study aimed to compare 68Ga-FAPI-46 PET/CT with 18F-FDG PET/CT for detecting primary cancer and metastatic lesions in patients with head and neck squamous cell carcinoma (HNSCC). Methods: Twelve patients and 28 patients with HNSCC underwent 68Ga-FAPI-46 and 18F-FDG PET/CT for initial staging and recurrence detection, respectively. The concordance and diagnostic accuracy of both tracers were analyzed. Semiquantitative parameters, including SUVmax, SUVmean, and tumor-to-background ratio, were compared. Fibroblast activation protein (FAP) expression tumor volume and total lesion FAP expression of 68Ga-FAPI-46 were compared with metabolic tumor volume and total lesion glycolysis of 18F-FDG, respectively. Differences between semiquantitative parameters were analyzed using paired t testing. Results: 68Ga-FAPI-46 PET/CT was 83.3% and 96.4% concordant with 18F-FDG PET/CT for initial staging and recurrence detection, respectively. Eighteen lesions had histopathologic validation, and both tracers displayed 100% sensitivity, 50% specificity, and 94.4% accuracy for lesion-based analysis. FAP expression tumor volume was greater than metabolic tumor volume (P < 0.05), but no significant differences were observed for the other parameters. Conclusion: 68Ga-FAPI-46 PET/CT showed good concordance with, and comparable diagnostic performance to, 18F-FDG PET/CT for initial staging and recurrence detection in HNSCC patients.

【 授权许可】

CC BY