Performance of 18 F-FAPI PET/CT in assessing glioblastoma before radiotherapy: a pilot study

BMC Medical Imaging

Research

Xiaofei Tan¹  Zhuzhong Cheng¹  Shirong Chen¹  Yutang Yao¹  Ying Kou¹  Xiaoxiong Wang¹  Jun Dang¹  Yongli Liu¹  Xiao Jiang²  Jun Yin³  Wenya Yin³ 

[1] Department of Nuclear Medicine, Sichuan Cancer Hospital&Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, No.55, Section 4, South People’s Road, 610041, Chengdu, Sichuan, China;Department of Nuclear Medicine, Sichuan Cancer Hospital&Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, No.55, Section 4, South People’s Road, 610041, Chengdu, Sichuan, China;Institute of Isotope, China Institute of Atomic Energy, 102413, Beijing, China;Department of Radiation Oncology, Sichuan Cancer Hospital&Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, No.55, Section 4, South People’s Road, 610041, Chengdu, China;

关键词: Glioblastoma;    FAPI;    PET/CT;    Metabolic parameters;    Molecular expression;    MRI;   

DOI  :  10.1186/s12880-022-00952-w

 received in 2022-09-05, accepted in 2022-12-14,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundWe aimed to determine the performance of 18 F-FAPI PET/CT used for preprocedural assessment of glioblastoma before radiotherapy.MethodsTwelve glioblastoma patients having undergone incomplete surgical resection or biopsy were examined with 18 F-FAPI PET/CT and MRI scanning before radiotherapy. All patients had confirmed tumor residues according to findings of histopathological and/or long-term clinical and radiological follow-ups. Lesion characterization data, including SUVmax and tumor-to-background ratio (TBR) on PET/CT were attained. PET/CT and MRI findings were compared in terms of number of lesions. The correlation between immunohistochemistry, molecular expression, and PET/CT parameters was also evaluated.Results18 F-FAPI PET/CT detected 16 FAPI-avid out of 23 lesions in 12 patients described on MRI. MRI was statistically different from 18 F-FAPI PET/CT for lesion detection according to the exact McNemar statistical test (P = 0.0156). The SUVmax and TBR of the glioblastomas was 7.08 ± 3.55 and 19.95 ± 13.22, respectively. The sensitivity and positive predictive value (PPV) of 18 F-FAPI PET were 69.6% and 100%, respectively. Neither the Ki-67 index nor the molecular expression was correlated with the FAPI-PET/CT parameters.Conclusion18 F-FAPI PET/CT detects glioblastomas at a lower rate than MRI. However, the 100% PPV of the examination may make it useful for differentiating controversial lesions detected on MRI. The 18 F-FAPI-avid lesions are displayed more clearly probably due to a higher TBR. 18 F-FAPI PET/CT imaging might find application in glioblastoma biopsy and radiotherapy planning.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

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Fig. 3