Dual-Tracer PET/CT Protocol with [ 18 F]-FDG and [ 68 Ga]Ga-FAPI-46 for Cancer Imaging: A Proof of Concept

The Journal of Nuclear Medicine

article

Simone Wegen¹  Klaus Schomäcker²  Thomas Fischer²  Simone Marnitz¹  Alexander Drzezga²  Carsten Kobe²  Katrin S. Roth²  Conrad-Amadeus Voltin²  Lutz van Heek² 

[1] Department of Radiation Oncology, Cyberknife, and Radiotherapy, Faculty of Medicine, University Hospital Cologne, University of Cologne;Department of Nuclear Medicine, Faculty of Medicine, University Hospital Cologne, University of Cologne

关键词: dual-tracer PET/CT;    FDG;    FAPI;   

DOI  :  10.2967/jnumed.122.263835

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Imaging studies with PET tracers acting as fibroblast activation protein inhibitors (FAPIs) show promising results that could usefully complement [18F]-FDG in cancer imaging. Methods: All patients received [18F]-FDG PET/CT and dual-tracer PET/CT after an additional injection of [68Ga]Ga-FAPI-46 after the [18F]-FDG PET/CT. Two readers visually compared detection rate and analyzed target-to-background ratios for tumor and metastatic tissue in single- and dual-tracer PET/CT. Results: Detection rate in dual-tracer PET/CT was visually as good as that in single-tracer PET/CT in 4 patients and superior in 2 patients, whereas target-to-background ratios were significantly higher in dual-tracer PET/CT. Conclusion: Dual-tracer [18F]-FDG/[68Ga]Ga-FAPI-46 PET/CT within a single session is feasible and has potential. The dual-tracer approach may have superior sensitivity to [18F]-FDG PET/CT alone without compromising individual assessment of either scan.

【 授权许可】

CC BY