Influence of Height on Risk and Outcome of Patients with Early Breast Cancer: A Pooled Analysis of 4,925 Patients from 5 Randomized Trials of the Austrian Breast and Colorectal Cancer Study Group (ABCSG)

Breast care

article

Gampenrieder, Simon P.¹  Pircher, Magdalena¹  Fesl, Christian³  Rinnerthaler, Gabriel¹  Mlineritsch, Brigitte¹  Greil-Ressler, Sigrun¹  Steger, Günther G.⁴  Sagaster, Verena⁴  Fitzal, Florian⁵  Exner, Ruth⁵  Devyatko, Yelena⁵  Balic, Marija⁶  Stöger, Herbert⁶  Suppan, Christoph⁶  Bauernhofer, Thomas⁶  Singer, Christian F.⁷  Pfeiler, Georg⁷  Seifert, Michael⁷  Helfgott, Ruth⁸  Heck, Dietmar⁸  Rumpold, Holger⁹  Kwasny, Werner^1,10  Wieder, Ursula^1,11  Gnant, Michael³  Greil, Richard¹ 

[1] Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Salzburg Cancer Research Institute – Laboratory for Immunological and Molecular Cancer Research ,(SCRI-LIMCR), Paracelsus Medical University Salzburg;Cancer Cluster Salzburg;Austrian Breast and Colorectal Cancer Study Group;Department of Internal Medicine 1, Division of Oncology, Comprehensive Cancer Center, Medical University of Vienna;Department of Surgery and Comprehensive Cancer Center, Medical University of Vienna;Division of Oncology, Department of Internal Medicine, Medical University of Graz;Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna;Department of Surgery and Breast Health Center;Department of Internal Medicine 2 with Medical Oncology, Hematology, Gastroenterology and Rheumatology, Academic Teaching Hospital Feldkirch;Department of Surgery, Wiener Neustadt Hospital;Department of Surgery, Hanusch Hospital Vienna

关键词: Early breast cancer;    Height;    Body mass index;    Risk;    Outcome;    Austrian Breast and Colorectal Cancer Study Group;    Disease-free survival;    Overall survival;   

DOI  :  10.1159/000516157

学科分类：泌尿医学

来源: S Karger AG

【 摘 要 】

Background: Associations between height, cancer risk and worse outcome have been reported for several cancers including breast cancer. We hypothesized that in breast cancer clinical trials, tall women should be overrepresented and might have worse prognosis. Methods: Data of 4,935 women, included from 1990 to 2010 in 5 trials of the Austrian Breast and Colorectal Cancer Study Group (ABCSG), were analyzed retrospectively. The primary objective was to determine differences in height distribution between the ABCSG cohort and the Austrian female population according to a cross-sectional health survey conducted by the Austrian Statistic Center in 2006 and 2007. Secondary endpoints were disease-free survival (DFS) and overall survival (OS) in different height classes and differences of body mass index (BMI) distribution. Results: Breast cancer patients in the ABCSG cohort were only slightly but statistically significantly smaller compared to unselected Austrian adult females (mean 164.3 vs. 164.8 cm; p < 0.0001) and significantly more patients were seen in the lower body height class (50 vs. 46%; p < 0.0001) when using the median as a cutoff. However, after adjustment for age, the difference in body height between the two cohorts was no longer significant (p = 0.089). DFS and OS in the two upper height groups (≥170 cm) compared to the two lowest height groups (<160 cm) was not significantly different (5-year DFS: 84.7 vs. 83.0%; HR 0.91, 95% CI 0.73–1.13, p = 0.379; 5-year OS: 94.8 vs. 91.7%; HR 0.74, 95% CI 0.55–1.00, p = 0.051). The BMI of ABCSG patients was significantly higher than in the reference population (mean BMI 24.64 vs. 23.96; p < 0.0001). Conclusions: Our results do not confirm previous findings that greater body height is associated with a higher breast cancer risk and worse outcome.

【 授权许可】

CC BY