Nano Capsule ?Novel Drug Delivery Approached In Cancer Therapy.

Research Journal of Pharmaceutical, Biological and Chemical Sciences

article

Dharm Jeet Yadav¹  Piyush Yadav¹  Manoj Kumar Yadav.¹ 

[1] Prasad Institute Of Technology, Department Of Pharmacy

关键词: Drug release;    Dosage forms;    Hydrogel;    Cancer therapy;    Novel drug delivery system;    Nanoparticles;   

DOI  :  10.33887/rjpbcs/2022.13.2.2

学科分类：工程和技术（综合）

来源: Research Journal of Pharmaceutical, Biological and Chemical Sciences

【 摘 要 】

Novel Drug Delivery Systems (NDDS) have numerous points of interest, which comprise bettertherapy by increasing the efficacy and duration of drug activity, improved patient compliance throughreduced dosing frequency. It provides appropriate routes of administration and enhanced targeting for aparticular site to anticipate hurtful reactions. The Different types of advanced drug delivery approach likepolymeric Nano capsules, nanoparticles, liposomes, nanoemulsion, microsphere, microcapsules,hydrogels has been expressed utilizing bioactive and plant extracts. NDDS have significant advantagesover conventional therapy for cancer treatment, which include improved solubility and bioavailability,low toxicity, maximum therapeutic effect, sustained and controlled drug delivery, improvement ofstability and batter security from physical and biochemical degradation. This article covers the basicinformation and different types of Novel Drug Delivery Systems Currently, a majority of cancer treatmentstrategies are based on the removal of tumor mass mainly by surgery. Chemical and physical treatmentssuch as chemo- and radiotherapies have also made a major contribution in inhibiting rapid growth ofmalignant cells. Furthermore, these approaches are often combined to enhance therapeutic indices. It iswidely known that surgery, chemo- and radiotherapy also inhibit normal cells growth. In addition, thesetreatment modalities are associated with severe side effects and high toxicity which in turn lead to lowquality of life. This review encompasses novel strategies for more effective chemotherapeutic deliveryaiming to generate better prognosis. Currently, cancer treatment is a highly dynamic field and significantadvances are being made in the development of novel cancer treatment strategies. In contrast toconventional cancer therapeutics, novel approaches such as ligand or receptor based targeting, triggeredrelease, intracellular drug targeting, gene delivery, cancer stem cell therapy, magnetic drug targeting andultrasound-mediated drug delivery, have added new modalities for cancer treatment. These approacheshave led to selective detection of malignant cells leading to their eradication with minimal side effects.Lowering, multi-drug resistance and involving influx transportation in targeted drug delivery to cancercells can also contribute significantly in the therapeutic interventions in cancer.

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