Physical characteristic and irritation index of Syzigium aromaticum essential oil in O/W and W/O creams

International Pharmacy Conference UAD 2017 on Product Authentication: Key Factor in Quality Control of Pharmaceutical Products

Safriani, R.^1 ; Sugihartini, N.^1 ; Yuliani, S.^1

Faculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, Indonesia^1

关键词: Anti-inflammatories;    cream;    Dosage forms;    Fusion methods;    irritation index;    Physical characteristics;    S. aromaticum;    Spreadability;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/259/1/012005/pdf
DOI  :  10.1088/1757-899X/259/1/012005

来源: IOP

【 摘 要 】

Essential oil of Syzigium aromaticum has been formulated in O/W and W/O creams as anti-inflammatory dosage form. The purpose of this study was to evaluate the physical characteristic and irritation index of S. aromaticum essential oil in O/W and W/O creams. The creams were made by fusion method. The creams then were evaluated the physical characteristic including pH, viscosity, spreadability and adhesivity. The irritation index was obtained by irritation skin test in male rabbit. The results showed that the W/O and O/W creams have the value of pH: 6.3 and 6.27; spreadability: 3,18 and 4.17 cm2; adhesivity: 5.59 and 0.07 minutes; viscosity: 4.43 and 2.88 Pa.S, respectively. The irritation test showed that the control enhancer caused mild irritation in both of W/O and O/W creams. These findings indicated that type of cream might influence the physical characteristic and irritation index of S. aromaticum essential oil cream.