Potency of Charcoal From The Body Part Kerandang(Channa pleurophthalma Blkr)Fish Which Is Not Eaten As An Antiallergy. Based On In Vitro, In Vivo and LC-HRMS

Research Journal of Pharmaceutical, Biological and Chemical Sciences

article

Aryani¹  Suprayitno E²  Sasmito BB²  Hardoko.² 

[1] Faculty of Agriculture, University of Palangka Raya, Central Kalimantan;Faculty of Fisheries and Marine Sciences, University of Brawijaya

关键词: Charcoal;    Kerandang fish;    antiallergy;   

DOI  :  10.33887/rjpbcs/2020.11.3.13

学科分类：工程和技术（综合）

来源: Research Journal of Pharmaceutical, Biological and Chemical Sciences

【 摘 要 】

Parts of an animal's body that are usually used as traditional medicine include: meat, horns, bones,tails, feathers, nails, fat, gall, and shells. The types of animals that have the potential to be developed asmedicines consist of several criteria, namely that animals are easily found, are still widely available innature.One method to treat allergies that have been carried down for generations in Central Kalimantan is touse charcoal from the body parts of the Kerandang fish that are not eaten such as the scalp, scales and fins.This research was conducted with the aim to find out the charcoal potency of the body parts of Kerandang(Channa pleurophthalma Blkr) fish from Central Kalimantan as an antiallergy drug.Testing coveredantihyaluronidase in vitro, in vivo in male mouse test animals, and identification of active compounds with LCHRMS. The results obtained: the highest inhibition (IC50) of hyaluronidase in ethyl acetate extract of fish caudalfins concentration 4 mg / ml, concentrate of 15 % from charcoal of fish caudal fins can pressure IgE expressionin male mouse. Identification of the active components of charcoal in the Kerandang fish caudal fins with LCHRMS found the active compound is Hexadecanamide.

【 授权许可】

All Rights reserved