Anti-Allergic Activity of a Platycodon Root Ethanol Extract

International Journal of Molecular Sciences

You-Chang Oh³  Ok-Hwa Kang³  Jang-Gi Choi³  Young-Seob Lee³  Obiang-Obounou Brice³  Hyun Ju Jung³  Seung-Heon Hong³  Young-Mi Lee³  Dong-Won Shin²  Yeong-Shik Kim¹ 

[1] Natural Products Research Institute College of Pharmacy, Seoul National University, Seoul 151-742, Korea; E-Mail:;Department of Oriental Medicine Resources, Sunchon National University, Jeonnam 540-742, Korea; E-Mail:;College of Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University, Iksan 570-749, Korea; E-Mails:

关键词: antiallergy;    Platycodon root;    bone marrow-derived mast cell;    prostaglandin D₂;    leukotriene C₄;    cyclooxygenase-2;   

DOI  :  10.3390/ijms11072746

来源: mdpi

【 摘 要 】

Platycodon grandiflorum (Campanulaceae) is used as traditional medicine in Asian countries. In Korean traditional medicine, Platycodon root has been widely used since ancient times as a traditional drug to treat cold, cough and asthma. However, its effects on bone marrow-derived mast cell (BMMC)-mediated allergy and inflammation mechanisms remain unknown. In this study, the biological effect of Platycodon root ethanol extract (PE) was evaluated in BMMC after induction of allergic mediators by phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187 (A23187) stimulation. The effect of PE on the production of several allergic mediators, such as interleukin-6 (IL-6), prostaglandin D₂ (PGD₂), leukotriene C₄ (LTC₄), β-Hexosaminidase (β-Hex) and cyclooxygenase-2 (COX-2) protein, was investigated. The results demonstrate that PE inhibits PMA + A23187 induced production of IL-6, PGD₂, LTC₄, β-Hexosaminidase and COX-2 protein. Taken together, these results indicate that PE has the potential for use in the treatment of allergy.

【 授权许可】

CC BY   
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.