Optimization of Solid Lipid Nanoparticles for the Encapsulation of Carotenoids from Cucurbita moschata Pulp

Engineering Proceedings

article

Nicola Pinna¹  Francesca Blasi¹  Aurélie Schoubben² 

[1] Section of Food Sciences and Nutrition, Department of Pharmaceutical Sciences, University of Perugia;Section of Pharmaceutical Chemistry and Technology, Department of Pharmaceutical Sciences, University of Perugia

关键词: nanoencapsulation;    binary mixture;    unconventional extraction;    pumpkin;    nanoparticles;    antioxidant properties;    β-carotene;    pharmaceutical technology;   

DOI  :  10.3390/ECP2023-14737

来源: mdpi

【 摘 要 】

This work aimed to optimize the production of Solid Lipid Nanoparticles (SLN) for the future encapsulation of carotenoid-rich extracts obtained from pumpkin (Cucurbita moschata) pulp by ultrasound-assisted extraction. The extracts were characterized by in vitro spectrophotometric assays and by high-performance liquid chromatography, coupled with a diode array detector. Hot high-pressure homogenization was the method selected for SLN production, and β-carotene was used as a model molecule for optimization. This choice was supported by chemical–analytical characterization, which identified β-carotene as the main carotenoid of the pumpkin extracts. SLN loaded with 1% β-carotene showed dimensions compatible with increased intestinal absorption. Furthermore, antioxidant assay results showed that the technological process did not alter the antioxidant capacity of β-carotene.

【 授权许可】

Unknown