Epigenetic Regulation in Breast Cancer: Insights on Epidrugs

Epigenomes

article

Ayoung Kim¹  Kyumin Mo¹  Hyeonseok Kwon¹  Soohyun Choe¹  Misung Park¹  Woori Kwak¹  Hyunho Yoon¹ 

[1] Department of Medical and Biological Sciences, The Catholic University of Korea;Department of Biotechnology, The Catholic University of Korea

关键词: epigenetic regulation;    epidrug;    breast cancer;    DNMT;    HDAC;   

DOI  :  10.3390/epigenomes7010006

学科分类：分子生物学，细胞生物学和基因

来源: mdpi

【 摘 要 】

Breast cancer remains a common cause of cancer-related death in women. Therefore, further studies are necessary for the comprehension of breast cancer and the revolution of breast cancer treatment. Cancer is a heterogeneous disease that results from epigenetic alterations in normal cells. Aberrant epigenetic regulation is strongly associated with the development of breast cancer. Current therapeutic approaches target epigenetic alterations rather than genetic mutations due to their reversibility. The formation and maintenance of epigenetic changes depend on specific enzymes, including DNA methyltransferases and histone deacetylases, which are promising targets for epigenetic-based therapy. Epidrugs target different epigenetic alterations, including DNA methylation, histone acetylation, and histone methylation, which can restore normal cellular memory in cancerous diseases. Epigenetic-targeted therapy using epidrugs has anti-tumor effects on malignancies, including breast cancer. This review focuses on the importance of epigenetic regulation and the clinical implications of epidrugs in breast cancer.

【 授权许可】

CC BY