Linking DNA methylation to the onset of human tubal ectopic pregnancy

American Journal of Translational Research

Yi Feng¹  Lei Wang¹  Lin He¹  Håkan Billig¹  Ruijin Shao¹  Mats Brännström¹  Shien Zou¹ 

关键词: DNA methylation;    DNMT;    implantation;    ectopic pregnancy;    fallopian tube;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Ectopic pregnancy is a common reproductive disorder of unknown etiology and is a leading cause of maternal and fetal mortality. Because of the asymptomatic nature of early tubal ectopic pregnancy and the lack of specific biomarkers for early diagnosis, a better understanding of the complex cellular and molecular interactions that contribute to tubal ectopic pregnancy is required. DNA methylation is the most studied epigenetic process in various tissues and cells, and the goal of this article is to provide a brief review of recent work describing the potential mechanisms of DNA methylation and the biological function of such methylation in normal intrauterine pregnancy. Further, novel findings from our laboratory highlight the possible role of DNA methylation in human Fallopian tube dysfunction and suggest a possible correlation between methylation of estrogen receptor α in women and the occurrence of tubal ectopic pregnancies.

【 授权许可】

Unknown